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FLASH GENE
Symbol COX4I2 contributors: mct/npt - updated : 23-05-2014
HGNC name cytochrome c oxidase subunit IV isoform 2 (lung)
HGNC id 16232
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Cox4b
Homologene
FAMILY
  • cytochrome c oxidase IV family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,nucleus
    basic FUNCTION
  • largest nuclear encoded subunit which plays a pivotal role in COX regulation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism energetic
    signaling
    a component
  • component of the cytochrome oxidace c (ferrocytochrome c : oxygen oxidoreductase) complex,terminal enzyme in the mitochondrial respiratory chain (oxidative phosphorylation OXPHOS), catalyzing the elctron transfer from reduced cytochrome c to molecule oxygen
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • in the nucleus CHCHD2 is a transactivator of COX4I2 and other hypoxia-stimulated genes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) COX4I2D
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS