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FLASH GENE
Symbol TLE2 contributors: npt/SGE - updated : 27-07-2010
HGNC name transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
HGNC id 11838
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • casein kinase II site/nuclear localization sequence motif with a pleckstrin homology (PH) domain
  • six WD repeats (Trp-Asp domains)
  • conjugated PhosphoP
    mono polymer homomer , heteromer , oligo
    HOMOLOGY
    interspecies homolog to Drosophila split Groucho (Notch signaling pathway)
    homolog to murine Tle2 (92.0pc)
    homolog to rattus Tle2 (91.6pc)
    Homologene
    FAMILY
  • GROUCHO/TLE family of WD-repeat proteins
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • inhibiting the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling
  • implicating these molecules in the maintenance of the undifferentiated state in epithelial cells (coexpressed with NOTCH)
  • transcrptional corepressor that binds to a number of transcription factors
  • inhibiting replication and transactivation mediated by RTA, providing another potentially important mechanism for maintenance of Kaposi's sarcoma-associated herpesvirus viral latency through interaction with a host protein (He 2010)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text
  • histogenesis and organogenesis
  • transcriptional corepressor
  • PATHWAY
    metabolism
    signaling signal transduction
    a component
  • homo-oligomer and hetero-oligomer with other family members
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to a number of transcription factors
  • binding to LEF1, TCF7, TCF7L1, TCF7L2, UTY, HES1 and HES5
  • cell & other
    REGULATION
    Other the effects of full-length TLE family members may be modulated by association with dominant-negative AES
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    elevated expression in cervical squamous metaplasias and carcinomas (Liu 1996)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS