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FLASH GENE
Symbol MAPK10 contributors: mct/pgu - updated : 20-06-2015
HGNC name mitogen-activated protein kinase 10
HGNC id 6872
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • tyrosine kinase catalytic domain
    • HOMOLOGY
    interspecies homolog to murine Mapk10
    Homologene
    FAMILY
  • protein kinase superfamily
  • CMGC Ser/Thr protein kinase family
  • MAP kinase subfamily
    • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • mediating apoptosis in central nervous system and role in the development of brain tumors
  • playing an established role in both neuronal differentiation and apoptosis
  • having a pivotal role in regulation of ceramide biosynthesis in cerebral ischemia/reperfusion
  • critical mediator of mutant HTT toxicity, providing a molecular basis for mutant HTT-induced inhibition of fast axonal transport
  • mediates activation of LASS6 in cerebral ischemia/reperfusion
  • critically involved in stress-induced deficit of contextual fear
  • important enzymes in the pathology of diverse neurological disorders
  • mediates potentially its effects mainly at the transcriptional level, while MAPK8 or MAPK9 appear to mediate their pro-apoptotic effect in the cytoplasm
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • components of the two MAPK cascades, MAP3K5-MAP2K4-MAPK10 and RAF1-MAPK1-MAP2K1 interacting with arrestins
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ARR3 (multiple residues on the non-receptor-binding side of ARR3 are crucial for MAPK10 activation)
  • protects beta-cells from apoptosis and dysfunction mainly through maintenance of a normal IRS2 to AKT2 signaling pathway
  • ARR3 binds MAPK10, MAP2K4, and MAP3K5
  • ARR3 promotes MAPK10 phosphorylation by MAP2K7
  • MAPK10 interacts with the non-receptor-binding side of ARR3
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in pharmacoresistant epileptic encephalopathy type Lennox-Gastaut
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker PPP2CB, MAPK10, RAC3 were independent prognostic factors for bladder cancer (BLCA)
    Therapy target
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in pharmacoresistant epileptic encephalopathy type Lennox-Gastaut
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker PPP2CB, MAPK10, RAC3 were independent prognostic factors for bladder cancer (BLCA)
    Therapy target
    ANIMAL & CELL MODELS
  • Jnk3 null mice showed an increase in pik3cb transcript and protein, together with an increase in PI3K activity and phosphorylation of AKT