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FLASH GENE
Symbol CTNND1 contributors: mct/pgu - updated : 17-06-2016
HGNC name catenin (cadherin-associated protein), delta 1
HGNC id 2515
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal head domain
  • a potential coiled-coil forming alpha-helix segment
  • a central domain with ten repeats of the Armadillo motif (ARM domains)
  • a C terminal tail domain, with a minimal sequence responsible for the recruitment of ARHGAP5 (herein referred to as CRAD, catenin-RhoGAP association domain)
  • HOMOLOGY
    interspecies homolog to murine Ctnnd1 (97.8pc)
    Homologene
    FAMILY
  • beta-catenin family, Armadillo gene family
  • CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text nuclear in particular cells (localize in the nucleus, although the nuclear function of p120 is not fully understood)
    basic FUNCTION
  • involved in cell structure and adhesion
  • may associate with and regulate the cell adhesion properties of both c- and e-cadherins
  • involved in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors
  • in association with GRLF1, regulating cadherin function
  • critical E-cadherin binding partner that stabilizes adherens junction strength
  • codependent role in regulating Rac-depedent antagonism of Rho
  • cadherin-associated protein that regulates Rho GTPases and promotes the invasiveness of E-cadherin-deficient cancer cells
  • physical interaction between CTNND1 and Rho-associated protein kinase 1 (ROCK1), a major effector of RHOA
  • essential role for CTNND1 in mammary morphogenesis
  • CTNND1 signaling in motor neurons promotes nerve-muscle interaction and neuromuscular junction (NMJ) assembly
  • stabilizes cadherins and demonstrate that CDH5 endocytosis is crucial for endothelial cell migration in response to an angiogenic growth factor
  • CTNND1, CTNNB1 have distinct but complementary roles in strengthening cadherin-mediated adhesion
  • modulates adherens junction (AJ) dynamics by controlling the stability of classical cadherins
  • potential roles for the CCDC85A, CCDC85B, CCDC85C and CTNND1 family members in development, motility, and/or adhesion
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • novel pathway in which SULF2 regulates tissue regeneration in part via the activation of a novel WNT1-GLI1-CCND1 pathway
  • a component
  • constituent of the E cadherin multiprotein complex
  • constituent of desmosomal plaque
  • component of adherens junctions
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cytoplasmic domain of cadherins
  • binding to and inhibiting the transcriptional repressor ZBTB33
  • interacting with GRLF1
  • interactor of the DSG proteins (DSG3), which may play a role in desmosome remodeling
  • directly binds to the intracytoplasmic domains of classical cadherins (promotes the stabilization of cadherin complexes on the plasma membrane and thus positively regulates the adhesive activity of cadherins)
  • interacting with GLIS2
  • ZNF703 interacting with CTNND1 (promotes expression of CTNND1 and alters CTNND1 localization upon cell contact with the extracellular matrix)
  • CTNNA1/CTNND1 contact within the cadherin-catenin complex can regulate cadherin trafficking
  • physical interaction between CTNND1 and Rho-associated protein kinase 1 (ROCK1), a major effector of RHOA
  • ubiquitination of CDH1 juxtamembrane domain inhibits CTNND1 binding, and targets CDH1 for degradation
  • binds to the cytoplasmic tails of classical cadherins and inhibits cadherin endocytosis
  • CDH5 interacts with CTNND1and CTNNB1 through its cytoplasmic tail
  • is a key effector of a RAS-PKCE oncogenic signaling axis
  • critical role for CTNND1 (AAs 820-843) domain in the CTNND1/ARHGAP5 signaling complex assembly, membrane targeting, and stimulation of ARHGAP5 activity toward inhibition of the Rho pathway
  • PLEKHA7 bound to MLLT4 in addition to CTNND1 and was associated with nectin by binding to MLLT4
  • interactions between CTNND1 and MUC1, and these interactions modulate dynamic properties of cell adhesion, motility, and metastasis of pancreatic cancer cells
  • interacts with CTNND1 and governs microtubule dynamics at adherens junctions
  • CTNND1 interacts with LEF1 and negatively regulates its transcriptional activity
  • new role for CTNND1 bound to the CDH2 precursor ensuring its trafficking through the biosynthetic pathway towards the cell surface
  • cell & other
    REGULATION
    activated by E2F1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    in high-grade submandibular gland neoplasia
    tumoral        
    in skin squamous cell carcinomas (associated with NFKB activation )
    tumoral     --over  
    during tumor progression contributes to the invasive phenotype of cadherin-deficient carcinomas
    Susceptibility to Non-Syndromic Cleft Lip with or without Cleft Palate (NS-CL/P)
    Variant & Polymorphism other
  • pathogenic variants identified in CTNND1 in cases of NS-CL/P
  • Candidate gene
    Marker
  • delocalization/loss of expression could be an independent prognostic marker in oral squamous cell carcinomas
  • cytoplasmic CTNND1, cytoplasmic ZBTB33, and nuclear MTA2 expression correlated directly with histological type and Masaoka stage and may thus be used as potential biomarkers to predict biological behavior of thymoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    N-terminal domain is a valid therapeutic target in cancer
    ANIMAL & CELL MODELS