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FLASH GENE
Symbol RGS19 contributors: mct - updated : 14-02-2011
HGNC name regulator of G-protein signaling 19
HGNC id 13735
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • N-terminal domain plays a crucial role in its receptor preference
  • one regulator of G protein signaling domain
  • multiple potential phosphorylation sites
  • cysteine string
  • C-terminal PDZ-binding motif
  • HOMOLOGY
    Homologene
    FAMILY
  • regulator of G-protein signaling family
  • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • inhibiting signal transduction by increasing GTP activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form
  • negatively regulate the signaling of many G protein-coupled receptors, including the opioid receptors
  • complex role for RGS19 in regulating the ability of WNT3A to signal to the level of beta-catenin and gene transcription
  • implicated in growth factor signaling through binding to GAIP-interacting protein C-terminus (GIPC1) via its C-terminal PDZ-binding motif
  • in addition to acting as a GAP, is able to stimulate cell proliferation in a GIPC1-dependent manner
  • influenced cardiac development and had negative effects on heart function
  • negatively affects and plays an important role in cardiac development and function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • specifically interacts with G protein, GAI3
  • recruited by GIPC1 to attenuate dopamine D2 receptor signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Rgs19 TG mice revealed abnormal ventricular development, including ventricular septal defect, a thin ventricular wall, and ventricular noncompaction