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FLASH GENE
Symbol RGS7 contributors: mct - updated : 09-03-2016
HGNC name regulator of G-protein signaling 7
HGNC id 10003
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one RGS domain
  • a GGL (G protein gamma subunit-like)domain, that recruits G beta(5)
  • a DEP/DHEX domain that mediates interactions with the membrane anchor proteins R7BP and R9AP , and punctate localization was mediated by the DEP/DHEX domains, and centrosomal localization was dependent on the DHEX domain
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Rgs7
    intraspecies homolog to EGLIO
    Homologene
    FAMILY
  • regulator of G protein family
  • subfamily R7
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    text
  • RGS7-GNB5 complex shuttled between plasma membrane and nucleus through RGS7BP binding
  • concentrated at the plasma membrane of cell bodies, in structures resembling lamellipodia or filopodia along the processes, and at the dendritic tips
  • had both diffuse cytosolic and punctate localization patterns and also localized in centrosomes
  • basic FUNCTION
  • crucial regulator of G-protein-coupled receptor signaling in the visual and nervous systems
  • RGS7, RGS11, and their binding partner GNB5 are localized to the dendritic tips of retinal ON bipolar cells (ON-BPC), and act in parallel to regulate the kinetics of ON bipolar cell responses, with differential impacts on the rod and cone pathways
  • RGS7 and RGS11 act in parallel to regulate the kinetics of ON bipolar cell responses, with differential impacts on the rod and cone pathways
  • RGS7 and RGS11 are the key GTPase accelerating proteins (GAPs) in the GRM6 pathway of retinal rod ON bipolar cells that set the sensitivity and time course of light-evoked responses
  • action of RGS7 and RGS11 is required for the generation of rod ON-BC light responses with high sensitivity and speed
  • GPR179 along with RGS7 and RGS11 controls the ability of the GRM6 cascade to gate TRPM1
  • RGS7, in cooperation with its binding partner RGS7BP, regulates GABABR-GIRK signaling in hippocampal pyramidal neurons
  • is a novel regulator of mu-opioid receptor (MOR) signaling by dissecting its circuit specific actions and pinpointing its role in regulating morphine reward by controlling the activity of nucleus accumbens neurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text promoting chondrocyte differentiation
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with GNB5 and forming an herterotrimer with the adition of RGS7BP
  • could form a homo-oligomer
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDCL seems to stabilize the interaction of GNB5 with TCP1 until GNB5 is folded, after which it is released to allow GNB5 to interact with RGS7
  • role of GNB5 in the retina, and likely in the entire nervous system, mediated exclusively by RGS7 proteins
  • GPR179, is required for DBC function and recruits the regulators of G-protein signaling (RGS) proteins, RGS7 and RGS11, to the dendritic tips of the depolarizing bipolar cells (DBCs)
  • GPR158 is an essential regulator of RGS7 in the native nervous system with a critical role in controlling its expression, membrane localization, and catalytic activity
  • GPR158 could bind to the RGS7 homo-oligomer without causing its dissociation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • RGS7(-/-) mouse is viable and fertile but smaller in body size