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FLASH GENE
Symbol LEPROTL1 contributors: mct/npt - updated : 21-10-2014
HGNC name leptin receptor overlapping transcript-like 1
HGNC id 6555
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • JAK binding site (Pro (46)-Ile-Pro(48) preceded by a cluster of hydropobic residues)
  • four potential transmembrane domains
  • HOMOLOGY
    intraspecies homolog to LEPR
    Homologene
    FAMILY
  • OB-RGRP/VPS55 family
  • tetraspanning membrane proteins family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • with LEPROT influence liver GH signaling and regulation of the genes encoding these proteins may constitute a molecular link between nutritional signals and GH actions on body growth and metabolism (Touvier 2009)
  • LEPROT and LEPROTL1 influence liver GH signaling and regulation of the genes encoding these proteins may constitute a molecular link between nutritional signals and GH actions on body growth and metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FGF21 prevents the GH effects on chondrocytes by activating LEPROT and LEPROTL1
  • FGF21 specifically and directly modulate LEPROT/LEPROTL1 expression and function in chondrocytes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS