basic FUNCTION
| critical for the spatially and temporally regulated transition in proliferation through differential regulation of PPP1CC and the cell cycle during neurulation and eye development |
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vmodulates integrin signaling and cofilin activity to coordinate the forces that drive enteric neural crest cell (ENCC) migration in the mammalian embryo |
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acts as a tumor suppressor that is deleted and mutant in several cancers |
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acts as a TSG to restrain cell proliferation and transformation and is inactivated in several types of cancers is a regulator of cell proliferation and exhibits characteristics of a tumor suppressor |
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inhibits protein phosphatase 1 and shows actin-binding activity |
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forms functional associations with intermediate filament networks in adult neural stem cells (NSCs) |