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FLASH GENE
Symbol SLC28A2 contributors: mct - updated : 15-04-2020
HGNC name solute carrier family 28 (sodium-coupled nucleoside transporter), member 2
HGNC id 11002
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminus tail is a domain implicated in transporter sorting (Cys(615) and Cys(649) are important residues for the proper trafficking of SLC28A2 to the plasma membrane)
  • HOMOLOGY
    interspecies homolog to murine Slc28a2
    intraspecies homolog to SLC28A1
    Homologene
    FAMILY SLC28A family of transporter
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • playing a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues
  • may have a significant role in uptake of nucleoside drugs from the intestine and is a potential transporter target for the development of nucleoside and nucleoside-mimetic drugs
  • mediate the uptake of anticancer and some antiviral drugs and are also suitable candidates to facilitate nucleoside-derived drug uptake into hepatocytes for detoxification
  • SLC28A1, SLC28A2 are pyrimidine and purine nucleoside-selective, respectively
  • plays an important role in the absorption, disposition, and biological effects of endogenous nucleosides and nucleoside analog drugs
  • is a high-affinity adenosine transporter that may play physiological roles beyond nucleoside salvage
  • is likely to modulate extracellular adenosine and cell energy balance in neuronal tissue
  • is a purine-preferring concentrative nucleoside transporter implicated in the regulation of extracellular adenosine levels and purinergic signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text purine nucleoside transporter
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDIA3 appeared to be a negative effector of SLC28A2 function, whereas ALDOB flux modulated SLC28A2 activity via a mechanism involving acquisition of higher affinity for its substrates
  • cell & other
    REGULATION
    inhibited by by formycin B
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    increases during gestation
    Susceptibility to gout
    Variant & Polymorphism other
  • associations of the SLC28A2 gene variant Rs16941238 with the Serum uric acid (SUA)level, hyperuricemia (HUA) and gout
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS