basic FUNCTION
| may playing a role in the regulation of cell growth |
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regulates synthesis of a specific subset of ceramides and displays a unique substrate specificity profile for chain length and/or saturation in fatty acid acyl-CoA |
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interplay among the CERS proteins (CERS2, CERS5, CERS6) in a stress stimulus-, cell type- and subcellular compartment-specific manner |
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important role for the CERS genes CERS2, CERS6) in breast cancer etiology or diagnosis |
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co-expression of CERS2 with CERS4/CERS6 reversed the inhibitory effect of long chain ceramides on cell proliferation and the induction of apoptosis |
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synthesis of very long chain ceramides is catalyzed by ceramide synthase 2 (CERS2) |
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is crucial for the maintenance of colon barrier function and epithelial integrity |
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Fatty acid elongase ELOVL1 and the ceramide synthase CERS2 were involved in C24:2 ceramide production |
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