Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol RAB4B contributors: SGE/npt - updated : 06-04-2010
HGNC name RAB4B, member RAS oncogene family
HGNC id 9782
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • Rab F motifs and Rab SF regions
    • conjugated LipoP
    HOMOLOGY
    interspecies homolog to rattus Rab4b (99.5 pc)
    homolog to murine Rab4b (99.5 pc)
    homolog to Drosophila Rab4 (75 pc)
    Homologene
    FAMILY
  • small GTPase superfamily
  • Rab family
  • RAS oncogene family
    • CATEGORY regulatory , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
    text lipid-anchor to the cytoplasmic side of the cell membrane
    basic FUNCTION
  • regulating vesicular trafficking pathways
  • important player in the control of SLC2A4 trafficking in adipocytes (difference in its expression in obese diabetic states could act as a compensatory effect to minimize the glucose transport defect in their adipocytes) (Kaddai 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text vesicular trafficking
    PATHWAY
    metabolism
    signaling
    a component
  • prenylated, methylated
    • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
    • protein
    cell & other
    REGULATION
    induced by the same regulatory machinery known to be essential for the expression of MHC class II genes
    Other regulated by a typical MHC class II-like enhancer
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Kawasaki disease
    Variant & Polymorphism SNP
  • rs2233152 near MIA and RAB4B highly associated to Kawasaki disease
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS