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FLASH GENE
Symbol ACBD3 contributors: - updated : 01-09-2007
HGNC name acyl-Coenzyme A binding domain containing 3
HGNC id 15453
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal PTB domain essential for NUMB activity
  • a proline-rich N terminal domain and an acyl-CoA-binding motif
  • a C terminal Golgi localization signal (NLS)
  • the GRID domain
  • a GOLGB1 binding domain
  • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY Golgin subfamily
    CATEGORY structural protein , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text
  • colocalized with GOLGB1 to the juxtanuclear region
  • associates with the Golgi Apparatus (localizing to the cytoplasmic face of the Golgi membranes)
  • becomes cytosolic only during mitosis
  • basic FUNCTION
  • involved in the maintenance of Golgi structure and function through its interaction with giantin (GOLGB1)
  • affecting protein transport between the endoplasmic reticulum and Golgi
  • functioning as an A-kinase anchoring protein (AKAP) critical in the cAMP-dependent steroid formation
  • may participate in PRKAR1A-mediated tumorigenesis and hypercortisolism
  • having roles in the Golgi, is involved in posttranslational modification and trafficking of proteins but not required for the process of Golgi fragmentation, which is essential for cell-cycle progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GOLGB1/giantin
  • interacting with NUMB through an essential NUMB domain (it is an essential NUMB partner in cell-fate specification)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS