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FLASH GENE
Symbol WNT16 contributors: mct/npt - updated : 28-03-2015
HGNC name wingless-type MMTV integration site family, member 16
HGNC id 16267
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to C.elegans W08d2.1
Homologene
FAMILY
  • WNT family
  • CATEGORY protooncogene , signaling
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    text associated with the extracellular matrix
    basic FUNCTION
  • ligand for members of the frizzled family of seven transemembrane receptors
  • plays an important role in leukemogenesis, raising its therapeutic interest
  • is an important determinant of cortical bone thickness (CBT) and bone mineral density (BMD), bone strength, and risk of fracture
  • is involved in intramembranous ossification and suppresses osteoblast differentiation through the Wnt/CTNNB1 pathway
  • regulates the somitic expression of two Notch ligands, deltaC (dlc) and deltaD (dld), whose combined function is required for HSC fate
  • antagonistic role for WNT16 in the chondrogenic transformation of vascular smooth muscle cells (VSMCs)
  • attenuates TGFB-Induced chondrogenic transformation in vascular smooth muscle
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis
    Susceptibility
  • to osteoporotic fractures
  • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS