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FLASH GENE
Symbol CYP4F12 contributors: mct/npt - updated : 30-06-2010
HGNC name cytochrome P450, family 4, subfamily F, polypeptide 12
HGNC id 18857
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated HemoP
mono polymer monomer
HOMOLOGY
intraspecies homolog to CYP4F2,CYP4F3
Homologene
FAMILY
  • cytochrome P450 family
  • multigenic cytochrome P450 superfamily of mixed-function monooxygenases
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • oxydizing arachidonic acid and eicosanoid
  • physiological roles of CYP4F3 and CYP4F12 in eosinophils are different (Kikuta 2007)
  • metabolically active toward inflammatory mediators and exogenous compounds such as antihistaminic drugs (Cauffiez 2004)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism drug , lipid/lipoprotein , other
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • NADPH, heme
  • protein
  • flavoprotein P450 oxidoreductase (POR)
  • interacting with NR1I2 (increased binding to NR1I2 in the presence of rifampicin) (Hariparsad 2009)
  • cell & other
    REGULATION
    Other regulated by NR1I2 (NR1I2 is involved in the regulation of CYP4F12 and along with SRC1 binds to a broad range of promoters but many of these are not inducible by rifampicin) (Hariparsad 2009)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS