basic FUNCTION
| playing an essential role in the src signaling pathway in various cells |
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its expression in dendritic cells is required for the induction of an optimal immune response |
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essential role for HSF4-mediated SKAP2 expression in the regulation of actin reorganization during lens differentiation, likely through a mechanism that SKAP2 anchors the complex of NCK2/focal adhesion to FGF receptors at the lamellipodium in lens epithelial cells (Zhou 2010) |
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hematopoietic adaptor protein that is necessary for macrophage migration, chemotaxis, global actin reorganization and local actin reorganization upon integrin engagement |
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macrophages require SKAP2 and SIRPA for integrin-stimulated cytoskeletal rearrangement |
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is a negative regulator of actin assembly and tumor invasion |
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negatively regulates cell migration and tumor invasion in fibroblasts and glioblastoma cells by suppressing actin assembly induced by the WASF2-CTTN complex |
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plays an important role in the control of actin assembly and cell migration |
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novel role of SKAP2 and its phosphorylation in the regulation of cellular motility |
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integrin activation by the FYB-SKAP2-signaling module controls the stability and duration of T cell-dendritic cell contacts during the progressive phases necessary for optimal T cell activation |