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FLASH GENE
Symbol PPP1R14A contributors: mct - updated : 06-04-2011
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 14A
HGNC id 14871
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
N terminal 67 residues highly conserved
conjugated PhosphoP
HOMOLOGY
interspecies homolog to murine Ppp1r14a
Homologene
FAMILY PP1 inhibitor family
CATEGORY protooncogene
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
basic FUNCTION
  • phosphorylation-dependent inhibitor of myosin phosphatase
  • causes a loss of merlin function characterized by merlin (NF2) phosphorylation, Ras activation and transformation
  • with DAPK3, participate in the regulation of PRKCA and PRKCE on vascular calcium sensitivity after hemorrhagic shock
  • playing a role in the regulation of endothelial cytoskeleton
  • phosphorylation-dependent inhibitor of smooth muscle myosin light chain
  • unique phosphoprotein that specifically inhibits myosin light chain phosphatase in smooth muscle and plays an essential role in agonist-induced contraction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PP1
  • GNB2L1 is a novel interaction partner of PPP1R14A
  • cell & other
    REGULATION
    Other phosphorylated by PKN
    cooperative increases in Ca2+ and G protein activation are required for a significant activation of total kinases that phosphorylate PPP1R14A, which together overcome PPP1R14A phosphatase activity and effectively increase the Ca2+ sensitivity of PPP1R14A phosphorylation and smooth muscle contraction
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS