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FLASH GENE
Symbol PPP1R3B contributors: mct/npt - updated : 13-04-2010
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 3B
HGNC id 14942
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal PP1-binding motif (RVSF) motif
  • a central glycogen-binding region
  • a C-terminal binding region for phosphorylase
  • HOMOLOGY
    intraspecies homolog to PPP1R3E,PPP1R3F,PPP1R3G
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may be contributing to the insulin-stimulated phosphatase activity in skeletal muscle
  • serine/threonine phosphatase involved in the modulation of glycogen synthesis in the liver and skeletal muscle (Dunn 2006)
  • target PP1 to glycogen and regulate its activity on enzymes of glycogen metabolism (Niimi 2007)
  • activates glycogen synthase regardless of glucose, does not regulate glycogen phosphorylase and stimulates glycogenesis in combination with insulin and glucose depletion (Montori-Grau 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    glycogen metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PP1
  • cell & other
    REGULATION
    activated by insulin
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS