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FLASH GENE
Symbol GCA contributors: npt/mct - updated : 07-01-2009
HGNC name grancalcin, EF-hand calcium binding protein
HGNC id 15990
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five EF-hand calcium-binding motifs
  • one potential phosphorylation
  • two potential glycosylation sites
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • sorcin/grancalcin/calpain light chain subfamily
  • penta-EF hand (PEF) family of calcium binding proteins
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • playing a role in granule-membrane fusion and degranulation
  • may be playing a role in regulation of adherence and migration of neutrophils
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • homodimer of 55kDa
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • with L-plastin (in a negative calcium dependant manner), a protein known to have actin bundling activity
  • cell & other associate with membranes in Ca(2+)-dependent manner
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS