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FLASH GENE
Symbol FZD8 contributors: npt/mct - updated : 04-09-2013
HGNC name frizzled homolog 8 (Drosophila)
HGNC id 4046
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal signal peptide
  • two Asn-linked glycosylation sites within the N-terminal extracellular region
  • lys-thr-X-X-X-thr motif involved in the activation of the WNT/beta-catenin signaling pathway
  • a fz domain involved in binding with WNT ligands
  • a CRD
  • seven transmenbrane domains
  • three N-linked glycosylation sites
  • a C-terminal ser/thr-X-val motif which is a binding site for scaffold proteins with multiple PDZ domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus Fzd8 (97.2 pc)
    homolog to murine Fzd8 (96.9 pc)
    intraspecies homolog to FZD5
    Homologene
    FAMILY
  • FZ/SMO family of G-protein coupled receptor
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • multi-pass membrane protein
  • basic FUNCTION
  • acting as a receptor for WNT proteins
  • coupled to the beta-catenin canonical signaling pathway, leading to the activation of dishvelled proteins, inhibition of GSK3 kinase, nuclear accumulation of beta-catenin and activation of WNT target genes
  • playing a role in several types of human cancer through activation of the beta-catenin-TCF pathway
  • may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues
  • may be functionally important for aberrant activation of the canonical Wnt signaling pathway in human lung cancer cells
  • may play an important role in aberrant activation of the canonical Wnt pathway which is critical for the proliferation and survival of lung cancer cells
  • FZD5 and FZD8 are involved in dose-dependent regulation of signaling in optic fissure/disc formation and progenitor expansion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling signal transduction
  • Wnt signaling pathway
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WNT receptor
  • scaffold proteins with multiple PDZ domains
  • interacting with GOPC
  • interacting with RSPO1 and RSPO3
  • binding to IGFBP4
  • IGFBP4 physically interacted with FZD8, and a Wnt co-receptor, LRP6, and inhibited the binding of WNT3A to FZD8 and LRP6
  • interacting with INVS (INVS is essential for the morphogenesis of the proximal and intermediate pronephric system and relays Frizzled-8–dependent signals to recruit Dishevelled to the plasma membrane)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in cervical uterus and lung cancers
    tumoral     --over  
    in acute lymphoblastic leukaemia (ALL)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    putative therapeutic target for human lung cancer
    ANIMAL & CELL MODELS