SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,outer
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,cytoskeleton,microtubule
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| text
| localized to intracytoplasmic membranes |
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sequestered to the microtubule-associated dynein motor complex |
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primarily localized to mitochondrial and cytoskeleton-associated fractions (pMID: 23152504) |
| basic FUNCTION
| regulator of cell death that operate at the mitochondrial membrane to control caspase activation, |
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involved in certain apoptotic responses and to prevent overproduction of hematopoietic cells |
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playing a role in neuronal and lymphocyte apoptosis |
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functionning as an essential initiator of the apoptosis in thymocyte-negative selection |
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involved in cytokine-dependent survival pathways |
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potent activator of apoptosis and, in neurons, induces the direct activation of BAX |
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with PMAIP1, establish a connection between FKHRL1 and mitochondria, and both BH3-only proteins are critically involved in FKHRL1-induced apoptosis in neuroblastoma  |
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transcriptionally and/or post-translationally induced in response to diverse apoptotic stimuli, such as cytokine deprivation or deregulated calcium flux, in a broad range of hematopoeitic, epithelial, and neuronal cell types |
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mediates motoneuron loss in a model of amyotrophic lateral sclerosis |
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implicated in the regulation of cell death induction in multiple cell types and tissues in response to a large number of stimuli, including growth factor or cytokine deprivation, calcium flux, ligation of antigen receptors on T and B cells, glucocorticoid or loss of adhesion |
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playing an important role in eliminating activated T cells even when IL2 is abundant, working in conjunction with Fas to eliminate chronically stimulated T cells and maintain immune homeostasis |
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critical sensor and mediator in the mitochondrial-dependent apoptosis |
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with BAX are required for GNB2L1-mediated mitochondrial cell death |
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proapoptotic member of the BCL2 family and is primarily involved in the regulation of the intrinsic apoptotic pathway |
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essential for the initiation of several pathways that induce apoptosis in thymocytes, including cytokine withdrawal and calcium flux |
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essential for thymocyte apoptosis caused by strong TCR stimulation and critical for negative selection of autoreactive thymocytes |
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its expression may be responsible for the inherent sensitivity of the developing retinal vasculature to changes in oxygen levels, and promotes vessel obliteration in response to hyperoxia |
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apoptosis regulated by BCL2L11- and PMAIP1-driven loss of MCL1 is thus the final step in neutrophil differentiation, required for the termination of neutrophil function and neutrophil-dependent inflammation |
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for optimal tumor suppressive activity, must be able to interact with all and not just select pro-survival BCL2 family members |
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has a major role in hematopoietic homeostasis, particularly in the lymphocyte compartment, where it strongly affects immune function |
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inhibits autophagy by recruiting Beclin 1 to microtubules |
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in response to toxic stimuli, is released from its interaction with DYNLL1 and can induce apoptosis by inactivating anti-apoptotic BCL2 proteins and by activating BAX-BAK1 |
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having a dual effects in inhibiting autophagy and promoting apoptosis and may have important roles in disease pathogenesis |
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plays a physiological role in promoting cell survival in addition to its well known function in apoptosis induction |
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BCL2L11 and BBC3 can directly activate the proapoptotic proteins BAX and BAK1 to permeabilize mitochondria, leading to caspase activation and apoptosis |
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BCL2L11 and BBC3 are the sentinels that interconnect kinase signaling networks and the mitochondrion-dependent apoptotic program, which offers therapeutic insights for designing novel cell death mechanism-based anticancer strategies |
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is required for cell death mediated by antimitotic agents |
