protein
| ERK5/PRKM7/MAP kinase |
|
interacting with MAP3K3 (activate the MAPK7 signal pathway by phosphorylating and activating MEK2K5) |
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activates MAPK7 and induces KLF4 to modulate TNF responses in dermal microvascular endothelial cells |
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REST promoted primordial germ cells (PGCs) survival via regulation of the MAP2K5 expression |
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MAPK7/MAP2K5 pathway mediates fluid shear stress induced RUNX2 expression in osteoblast differentiation |
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XIAP directly interacts with MAP3K3 and competes with PB1 domain-mediated binding to MAP2K5 |
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activation of the MAPK7/MAP2K5 pathway with CSF1R is required for osteoclast differentiation, which may induce differentiation through the induction of FOS |
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both CCM2L and CCM2 interfere with MAP3K3 activation and its ability to phosphorylate MAP2K5, a downstream target |