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FLASH GENE
Symbol MAP2K5 contributors: mct/npt/pgu - updated : 27-03-2018
HGNC name mitogen-activated protein kinase kinase 5
HGNC id 6845
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 11 conserved kinase subdomains in the catalytic domain
  • a PB1 domain in the N-terminus, they form a heterodimer via PB1-PB1 domain interaction that was reported to be indispensable to the activation of MAP2K5
  • HOMOLOGY
    interspecies homolog to murine Map2k5
    homolog to C.elegans Y54E10BL.6
    Homologene
    FAMILY
  • protein kinase superfamily
  • STE Ser/Thr protein kinase family
  • MAP kinase kinase subfamily
  • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    basic FUNCTION
  • serine/threonine protein kinase
  • CCM2L and CCM2 cooperate to regulate the activity of MAP3K3
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • activation of MAP2K5/MAPK7 signaling strongly inhibits endothelial cells migration and results in massive morphological changes
  • YAP1 promotes myogenic differentiation via the MAP2K5-MAPK7 pathway
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ERK5/PRKM7/MAP kinase
  • interacting with MAP3K3 (activate the MAPK7 signal pathway by phosphorylating and activating MEK2K5)
  • activates MAPK7 and induces KLF4 to modulate TNF responses in dermal microvascular endothelial cells
  • REST promoted primordial germ cells (PGCs) survival via regulation of the MAP2K5 expression
  • MAPK7/MAP2K5 pathway mediates fluid shear stress induced RUNX2 expression in osteoblast differentiation
  • XIAP directly interacts with MAP3K3 and competes with PB1 domain-mediated binding to MAP2K5
  • activation of the MAPK7/MAP2K5 pathway with CSF1R is required for osteoclast differentiation, which may induce differentiation through the induction of FOS
  • both CCM2L and CCM2 interfere with MAP3K3 activation and its ability to phosphorylate MAP2K5, a downstream target
  • cell & other
    REGULATION
    activated by phosphorylation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    associated with aggressive prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS