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FLASH GENE
Symbol LYVE1 contributors: mct - updated : 02-04-2008
HGNC name extracellular link domain containing 1
HGNC id 14687
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a leader peptide,
  • a 212-residues extracellular domain with seven cysteine residues
  • a serine/threonine-rich region and two potential N-linked glycosylation sites
  • a twenty-one amino acid transmembrane domain and a sixty-three-residues cytoplasmic tail
  • conjugated GlycoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to murine Xlkd1
    intraspecies homolog to cd44
    Homologene
    FAMILY
    CATEGORY adhesion , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • receptor for the glycoaminoglycan hyaluroman
  • playing a role in the regulation of lymphatic vascular function
  • may be playing a role in the autocrine regulation of cell growth of endothelial cells during formation of vessels
  • can function independently of hyaluronan and have implications for the use of LYVE1 as a histological marker for lymphangiogenesis in human pathology
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS development
    text embryonic development
    PATHWAY
    metabolism
    signaling
    a component disulfide-linked homodimer
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • hyaluronan
  • binding IGFBP3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    liver cancer, cirrhosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS