basic FUNCTION
| glycosaminoglycan binding activity |
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can activate coagulation factor VII and prourokinase and release the vasoactive peptide bradykinin by cleaving kininogen |
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undergoes autoactivation in the presence of polyanionic macromolecules such as heparin and RNA |
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negatively regulates vascular integrity via activation of protease-activated receptor/RHOA/RHO kinase signaling |
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serine protease implicated in proteolysis under inflammatory conditions |
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circulating serine protease with high homology to fibrinolytic enzymes |
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important role in the regulation of the haemostasis system as well as fibroproliferative inflammatory processes |