basic FUNCTION
| transmembrane receptor, heat stable enterotoxin receptor, regulating chloride secretion |
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intestinal receptor for the paracrine hormones guanylin and uroguanylin that converts guanosine-5prime-triphosphate to cyclic guanosine monophosphate (cGMP) |
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tumor suppressor that controls proliferation and metabolism of intestinal epithelial cells by inactivating AKT signaling |
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its signaling plays a protective role in the integrity of the intestinal mucosal barrier by regulating MLCK (myosin light chain kinase) activation and TJ (tight junction) disassembly |
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role for GUCY2C signaling in facilitating mucosal wounding and inflammation |
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regulator of ion and fluid balance in the intestine |
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is a multidomain, membrane-associated receptor guanylyl cyclase |