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FLASH GENE
Symbol GATM contributors: mct - updated : 29-05-2013
HGNC name glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HGNC id 4175
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
secondary structure five beta-beta-alpha-beta modules
HOMOLOGY
Homologene
FAMILY
  • amidinotransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,interspace
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • first step of the creatine synthesis resulting in the formation of guanidinoacetate
  • major part of endogenous synthesis of creatine is thought to occur in kidney, pancreas and liver, the brain widely expresses GATM, GAMT and SLC6A8, both during development and in adulthood
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GATM
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in all heart failure
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascular  
    specific response to heart failure involving elevated local creatine synthesis (implications both for the management of recovery patients undergoing combination therapy and for heart failure in general)
    ANIMAL & CELL MODELS
  • Agat-deficient mice exhibited decreased fat deposition, attenuated gluconeogenesis, reduced cholesterol levels, enhanced glucose tolerance, and reduced muscular nucleoside triphosphate (NTP) concentrations compared with wt mice