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FLASH GENE
Symbol NUP153 contributors: mct - updated : 29-12-2017
HGNC name nucleoporin 153kDa
HGNC id 8062
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal region within which a pore targeting domain
  • cytoplasmic O-linked N-acetylglucosamine residues
  • four apparent zinc finger domains
  • a novel RNA binding domain, a 150-amino acid region previously found to bind preferentially to a panel of mRNAs when compared with structured RNAs, such as tRNA, U snRNA, and double-stranded RNA
  • C-terminal region containing multiple XFXFG repeats (33 copies of the pentapeptide XFXFG), and a C-terminal part of NUP153 is required for effective TP53BP1 nuclear import
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Nup153
    Homologene
    FAMILY
    CATEGORY structural protein , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    intracellular,nuclear envelope,pore
    text intranuclear side of the pore, located to the terminal ring structure of the nucleoplasmic cage
    basic FUNCTION
  • required for nuclear pore complex anchoring within the nuclear envelop and in mediating specific nuclear import events
  • mediate the regulated movement of macromolecules between the nucleus and cytoplasm
  • mobile nucleoporin implicated in RNA export
  • has separable roles in both early mitotic progression and the resolution of mitosis
  • NUP153 levels regulate the localization of MAD1L1 during the metaphase/anaphase transition thereby affecting its phoshorylation status and in turn spindle checkpoint activity and mitotic exit
  • has a role in repair of DSBs and in the activation of DNA damage checkpoints
  • central function of NUP153 in the organization of the nucleus, not only at the periphery, but throughout the entire nuclear interior
  • chromatin-associated role of NUP153 in maintaining stem cell pluripotency by functioning in mammalian epigenetic gene silencing
  • NUP133 and NUP153 play different roles in assembling the nuclear pore complex (NPC) on membrane fenestrations
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text nucleocytoplasmic transport bidirectional
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of nuclear pore complex
  • member of SPI1.RanGTP.NUP153 complex)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding lamin B, LAMB3 during lamina assembly binding importin alpha/beta, transportin (karyopherin KPN, TRN2)
  • interacting with SPI1 (formation of a SPI1.RanGTP.NUP153 complex)
  • interaction of NUP153 with the spindle assembly checkpoint protein MAD1L1 is important in the regulation of the spindle checkpoint
  • DICER1 associates with NUP153(this association is detected predominantly in the cytoplasm but is also clearly distinguishable at the nuclear periphery), and NUP153 plays a crucial role in the nuclear localization of the DICER1 protein
  • both the N-terminal and the C-terminal domain of NUP153 are directly interacting with the lamins, suggesting that NUP153 may play a role in lamin-associated diseases
  • TP53BP1 is imported to the nucleus through the NUP153-KPNB1 interplay
  • NUP153 binds to both SENP1 and SENP2 and does so by interacting with the unique N-terminal domain of NUP153 as well as a specific region within the C-terminal FG-rich region
  • interaction between NUP50 and a region in the unique N-terminal region of NUP153 is critical for the nuclear pore localization of NUP50
  • KPNB1 and NUP153 interact at the nuclear pore complex (NPC) nuclear face to form a Ran-regulated mesh that modulates NPC permeability
  • nuclear transport receptor TNPO and the small GTPase RAN regulate the interaction of NUP153 with the membrane and, in this way, direct pore complex assembly to the nuclear envelope during interphase
  • only NUP153 is needed for proper nuclear import of TP53BP1 and SENP1-dependent sumoylation of TP53BP1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --other  
    alterations in specific proteins (NDC1, NUP160, NUP153 and NUP93) in ischaemic and dilated human heart
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    potential as a novel therapeutic target in cancers
    ANIMAL & CELL MODELS