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FLASH GENE
Symbol MYO1B contributors: mct - updated : 21-05-2012
HGNC name myosin IB
HGNC id 7596
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a myosin head-like domain
  • six IQ domains, binding calmodulin with a range of affinities
  • mono polymer complex
    HOMOLOGY
    interspecies homolog to rattus Myo1b (95.9 pc)
    homolog to murine Myo1b (97.9 pc)
    Homologene
    FAMILY myosin superfamily
    CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytoskeleton
    text
  • concentrates on endosomal and ruffling membranes
  • associates with the plasma membrane and certain subcellular organelles such as endosomes and lysosomes
  • basic FUNCTION
  • participating in process critical to neuronal development
  • functioning such as cell migration, neurite outgrowth and vesicular transport
  • controls the traffic of protein cargo in multivesicular endosomes most probably through its ability to modulate with actin the morphology of these sorting endosomes
  • play roles in membrane trafficking and dynamics
  • may play a role in the local midgut response pathway of the Imd innate immune response to Gram-negative bacterial infection
  • is substantially more tension-sensitive than other myosins with similar length lever arms, indicating that different myosins have different tension-sensitive transitions
  • regulates the actin-dependent post-Golgi traffic of cargo, generates force that controls the assembly of F-actin foci and, together with the actin cytoskeleton, promotes the formation of tubules at the trans-Golgi network
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • myosin complex
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • binding to acting
  • binding to calmodulin
  • binding of MYO1B to phosphoinositides plays an important role in vivo by regulating localization to actin-enriched membrane projections
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS