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FLASH GENE
Symbol KCNK16 contributors: mct/npt - updated : 03-03-2009
HGNC name potassium channel, subfamily K, member 16
HGNC id 14464
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two pore-forming P domains
  • four transmembrane segments
  • HOMOLOGY
    Homologene
    FAMILY
  • tandem-pore K+ channel family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • two-pore region (2P) KCNK K+ channel gated open by extracellular alkalinization (Niemeyer 2007)
  • may serve as background K+ currents in certain cells of the pancreas (Han 2003)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by alkaline PH
    strongly and specifically activated by nitric oxide superoxide anion and singlet oxygen (Duprat 2005)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS