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FLASH GENE
Symbol GNA12 contributors: npt/mct - updated : 19-09-2016
HGNC name guanine nucleotide binding protein (G protein) alpha 12
HGNC id 4380
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal mitochondrial targeting sequence
  • PKD1 interaction sites are likely to reside on exposed regions within the G protein helical domain
  • secondary structure three units (alpha, beta, gamma)
    conjugated LipoP
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to C.elegans F18G5.3
    homolog to murine Gna12
    Homologene
    FAMILY
  • G-alpha family
  • CATEGORY protooncogene , signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • modulator or transducer in various transmembrane signaling systems
  • heterotrimeric G protein alpha subunit specifically targeted to mitochondria and involved in the control of mitochondrial morphology and dynamics
  • important regulator of prostate cancer invasion
  • has a major role in regulating epithelial cell apoptosis through PP2A and JNK activation leading to loss of BCL2 protein expression
  • involved inbstress fiber formation and neurite retraction
  • regulated expression of HTR7 and GNA12-protein may represent a molecular mechanism by which serotonin
  • modulates IgG production, thus induces IgG antibody-mediated immune responses
  • may be a critical signaling molecule in TCR-induced IL2 production and also relay a signal to suppress Th2 and Th17 cell differentiation
  • specifically modulates formation of initial neuronal networks during early postnatal development
  • GNA12 and GNA14 play a key role in the genetic architecture underlying normal gray matter density (GMD) variation in frontal and parietal regions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DRD3 interaction with GNA12/GNA13 that increases sodium excretion may have a role in the regulation of blood pressure
  • MAPK8 activation is required for GNA12-induced invasion of breast cancer cells and MAPK8 is downstream of ROCK1 on this pathway
  • GNA12 plays a prominent role in endothelial cells (ECs) VWF secretion required for hemostasis and thrombosis
  • interaction of polycystin-1 (PKD1) and GNA12 is important for development of kidney cysts in autosomal dominant polycystic kidney disease (ADPKD)
  • CDH1/CTNNB1 signaling pathway is regulated by PKD1 and GNA12 via ADAM10
  • GPR56 regulates oligodendrocyte development via interactions with GNA12/GNA13 and RHOA
  • RGS22 had specific interactions with the heterotrimeric G protein GNA12 and GNA13 in the cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate cancer
    constitutional     --over  
    higher in preeclampsia patients than in controls, by decreased methylation level
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target may be targeted to limit invasion- and metastasis-induced prostate cancer patient mortality
    ANIMAL & CELL MODELS