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FLASH GENE
Symbol GNG11 contributors: npt/mct - updated : 15/102008
HGNC name guanine nucleotide binding protein (G protein), gamma 11
HGNC id 4403
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
secondary structure alpha, beta, gamma subunit
mono polymer heteromer , trimer
HOMOLOGY
interspecies homolog to C.elegans K02A4.2
Homologene
FAMILY
  • G protein gamma family
  • CATEGORY signaling , receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • plays a role in the transmembrane signaling system
  • mediating a senescence pathway in response to environmental cues
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heterotrimeric G protein complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by senescence-inducing agents such as H(2)O(2)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in splenic marginal zone lymphomas
    constitutional     --over  
    immediately induces cellular senescence in normal fibroblasts, and its down-regulation by antisense cDNA extends their lifespan
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS