basic FUNCTION
| executing the initial step of microRNA (miRNA) processing in the nucleus, that is cleavage of pre-miRNA to release pre-miRNA |
|
involved in endonucleolytic cleavage to 5'-phosphomonoester |
|
regulates cell proliferation and affects survival in esophageal cancer patients (Sugito 2006) |
|
miRNA processing enzyme that are required for the maturation of miRNAs (Kuehbacher 2007) |
|
significantly increased the expression of thrombospondin-1 (Kuehbacher 2007) |
|
required in the first step of microRNA (miRNA) processing in the nucleus (Scotto 2008) |
|
multiple functions for DROSHA and DICER1 in suppressing DNA damage in rapidly proliferating follicular matrix cells, facilitating catagen and maintaining follicular structures and their associated stem cells |
|
is essential mainly for the canonical miRNA production, and DROSHA-mediated miRNA production is essential for normal spermatogenesis and male fertility |
|
regulates neurogenesis by controlling NEUROG2 expression independent of microRNAs |
|
DICER1 and DROSHA RNA products control DNA-damage response (DDR) activation and act independently from canonical microRNA-mediated translational repression mechanisms |
|
potentially plays an important role breast cancer progression and assessment of its expression provides an independent predictor of patient outcome |
|
cleaves double-stranded primary miRNA by interacting with double-stranded RNA binding protein DGCR8 and processes primary miRNA into precursor miRNA to participate in the miRNA biogenesis pathway |
|
is required for vascular smooth muscle cell survival by targeting multiple signaling pathways |
|
main RNase III-like enzyme involved in the process of microRNA (miRNA) biogenesis in the nucleus |
|
RNA cleavage-independent function of Drosha in the regulation of human gene expression |
|
DROSHA can function like a splicing enhancer and promote exon inclusion |
|
promotes skipping of the overlapping exon in human cells independently of its cleavage function |