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FLASH GENE
Symbol PKP4 contributors: mct - updated : 27-09-2017
HGNC name plakophilin 4
HGNC id 9026
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nine ARM repeats
  • a conserved central domain consisting of a series of repeated motifs, the armadillo repeats, which is flanked by more diverse N- and C-terminal domains
  • HOMOLOGY
    interspecies homolog to rattus Pkp4 (96.6 pc)
    homolog to murine Pkp4 (96.6 pc)
    Homologene
    FAMILY
  • Armadillo proteins family
  • p120 catenin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,adherens
    plasma membrane,junction,desmosome
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    text
  • myofibrils
  • colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells
  • localized as a plaque protein in adhaerens junctions (AJs) of diverse epithelia and certain vascular endothelia, in the composite junctions (areal compositae) of the intercalated disks of cardiomyocytes
  • junctional plaque component involved in cell-cell adhesion, especially in adherens junctions
  • basic FUNCTION
  • regulating functional plaque organization and cadherin function
  • playing an essential role in spatially regulating restricted Rho signalling during cytokinesis
  • armadillo protein that is localized at the midbody during cytokinesis and is essential for cell division
  • plays a role in cytokinesis, in which it regulates local activation of RHOA together with ECT2
  • PKP4 and ECT2 are transported via distinct motors, identifying a novel pathway implicating KIF3B in the regulation of actin organization during cytokinesis
  • is an intercellular junction protein of the p120 catenin family
  • has likely a key role in regulating recycling through the RAB11A-dependent perinuclear recycling compartment, and links the regulation of adherens junctions to recycling to allow dynamic modulation of intercellular adhesion
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with PDZD2
  • full activation of RHOA required ECT2 as well as PKP4 indicating that these two proteins act in conjunction to regulate RHOA during cytokinesis
  • PKP4 is a potential novel FLCN interacting protein
  • is an important and novel FMR1 target, strongly suggesting that impaired actin cytoskeletal functions mediated by an excess of PKP4 are key aspects underlying the fragile X syndrome
  • RAB11A is a novel interaction partner of PKP4
  • directly interacts with the KIF3/subunit KIF3B, and also interacts with the kinesin cargo adaptor protein KIFAP3 acting as a stabilizing linker between KIF3B and its KIFAP3 cargo binding entity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS