SUBCELLULAR LOCALIZATION
| plasma membrane,junction,adherens
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| plasma membrane,junction,desmosome
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| intracellular
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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text
| myofibrils |
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colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells |
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localized as a plaque protein in adhaerens junctions (AJs) of diverse epithelia and certain vascular endothelia, in the composite junctions (areal compositae) of the intercalated disks of cardiomyocytes |
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junctional plaque component involved in cell-cell adhesion, especially in adherens junctions |
basic FUNCTION
| regulating functional plaque organization and cadherin function |
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playing an essential role in spatially regulating restricted Rho signalling during cytokinesis |
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armadillo protein that is localized at the midbody during cytokinesis and is essential for cell division |
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plays a role in cytokinesis, in which it regulates local activation of RHOA together with ECT2 |
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PKP4 and ECT2 are transported via distinct motors, identifying a novel pathway implicating KIF3B in the regulation of actin organization during cytokinesis |
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is an intercellular junction protein of the p120 catenin family |
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has likely a key role in regulating recycling through the RAB11A-dependent perinuclear recycling compartment, and links the regulation of adherens junctions to recycling to allow dynamic modulation of intercellular adhesion |