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FLASH GENE
Symbol EIF2S2 contributors: mct - updated : 19-02-2019
HGNC name eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
HGNC id 3266
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a highly charged N terminal region composed of three basic polylysine blocks separated by acidic domains
  • putative GTP binding sites
  • a zinc finger motif
    • mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to C.elegans K04G2.1
    Homologene
    FAMILY
  • EIF2 beta/EIF5 family
    • CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    basic FUNCTION
  • functions as a transcription initiation factor
    • CELLULAR PROCESS protein, translation/synthesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterotrimer composed of an alpha, beta and a gamma chain
    • INTERACTION
    DNA
    RNA
  • binding to initiator tRNA
  • binding to 40S ribosomal subunit
    • small molecule
    protein
  • binding to 40S ribosomal subunit
  • EIF5-CTD interacts directly with the translation initiation factors EIF1, EIF2S2, and EIF3C, thus forming together with EIF2S2 bound Met-tRNA(i)(Met) the multifactor complex (MFC)
  • role of EIF5-CTD dynamic interplay with EIF1 and EIF2S2 in switching PICs from an open to a closed state at start codons
  • CDC123 is critical for EIF2S1, EIF2S2, EIF2S3 activity, and CDC123 is a specific EIF2 assembly factor indispensable for the onset of protein synthesis
  • addition of CXCL12 leads to the dissociation of EIF2S2 from CXCR4 suggesting that stimulation of the receptor may trigger the local protein synthesis required for efficient cell movement
  • importance of EIF5 GDI (GDP-dissociation inhibitor) activity, and EIF2S2 acts in concert with EIF5 to prevent premature release of GDP from EIF2S3 and thereby ensure tight control of protein synthesis initiation
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification --over  
    in lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    is a therapeutic target for lung cancer
    ANIMAL & CELL MODELS