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FLASH GENE
Symbol TMEM123 contributors: KTN/npt - updated : 15/12/2008
HGNC name transmembrane protein 123
HGNC id 30138
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extracellular domain containing many O-linked
  • seven N-linked-glycosilation sites
  • hydrophobic transmembrane domain (ZOAA)
  • a cytoplasmic tail
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to dog TMEM123 (61.7 pc)
    homolog to chimpanzee TMEM123 (98.6 pc)
    homolog to cow TMEM123 (63.5 pc)
    homolog to rattus Tmem123 (57.1 pc)
    homolog to murine Tmem123 (56.6 pc)
    intraspecies homolog to CD164, endolyn
    Homologene
    FAMILY
  • membrane mucin family
  • CD164 family
  • CATEGORY regulatory , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text single-pass type I membrane protein
    basic FUNCTION
  • implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS