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FLASH GENE
Symbol EFNA3 contributors: mct - updated : 04-02-2012
HGNC name ephrin-A3
HGNC id 3223
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY signaling , receptor membrane
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
text GPI anchored, membrane protein
basic FUNCTION
  • membrane bound (glycosyl-phosphatidylinositol linkage) ligand for Eph-related kinase receptor tyrosine
  • EFNA2, EFNA3, EFNA5, and neural activity act together to control patterning of eye-specific retinogeniculate layers
  • physiological role for heparan sulfate proteoglycans in the regulation of EFNA3-dependent biological processes
  • involved in short-range contact-mediated axonal guidance
  • playing a specific role in postnatal neurogenesis
  • potentially acting as a repulsive cue that restricts cortical interneurons from entering inappropriate regions and thus contributing to define the migratory route of cortical interneurons
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • EPHA4/EFNAA3 signaling is potentially a critical mechanism for astrocytes to regulate synaptic function and plasticity
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • EPHA7
  • binds to heparan sulfate, and the presence of cell surface heparan sulfate is required for the full biological activity of EFNA3
  • interaction between neuronal EPHA4 and glial EFNA3 bidirectionally controls synapse morphology and glial glutamate transport, ultimately regulating hippocampal function
  • interactions between the ephrin-A3 ligand and the EPHA4 receptor regulate the structure of excitatory synaptic connections through neuroglial cross-talk
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS