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FLASH GENE
Symbol CETN3 contributors: mct - updated : 18-01-2011
HGNC name centrin, EF-hand protein, 3 (CDC31 homolog, yeast)
HGNC id 1868
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • EF-hand, Ca2+ binding protein
  • HOMOLOGY
    Homologene
    FAMILY
  • EF-hand superfamily of Ca2+-binding proteins
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome,centromere
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • distal lumen of centrioles
  • associated with centrosome-related structures
  • basic FUNCTION
  • Ca(2+) sensor protein, involved in the early process of centriole assembly, as they are concentrated within the precursor structures of centriole/basal bodies
  • able to bind strongly to a model target peptide (melittin), as well as to peptides derived from the protein XPC, with a moderate Ca(2+) dependence
  • CELLULAR PROCESS cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the centrosome of the interphase cells and mitotic spindle poles at mitosis
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • assemble into protein complexes with the visual heterotrimeric G-protein transducin, interaction mediated by binding to the betagamma-dimer of the heterotrimeric G-protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS