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FLASH GENE
Symbol SEMA4B contributors: mct - updated : 06-03-2007
HGNC name sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
HGNC id 10730
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a sema domain
  • a PSI domain
  • an immunoglobulin-like C2-type domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to chimpanzee SEMA4B (98 pc)
    homolog to rattus Sema4b (86.5 pc)
    homolog to murine Sema4b (84.1 pc)
    Homologene
    FAMILY
  • semaphorin family
  • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • type I membrane protein
  • basic FUNCTION
  • inhibiting axonal extension by providing local signals to specify territories inaccessible for growing axons
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    text
  • nervous system development
  • PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with DCBLD2 (regulation of DCBLD2 protein by ubiquitination and proteasome degradation enhanced in the presence of SEMA4B)(Nagai 2007)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS