protein
| CDC2 (negative egulator of CDC2) |
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zyxin (ZYX, to control mitosis progression by forming a regulatory complex or mitotic apparatus) |
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MOBKL1A |
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MOBKL1B |
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interacts with MOB1A, a protein whose homologue in budding yeast associates with kinases involved in mitotic exit |
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can negatively regulate transcription regulation and transformation functions of YAP1 by inhibiting its nuclear translocation via phosphorylation of multiple sites in YAP1 |
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interacting with the protein/discs-large protein/zonula (PDZ) domain of HTRA2 and promoting its protease activity |
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substrate for HTRA2 protease activity, thus it is not only a regulator but also a downstream target of this protease |
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LATS1 and LATS2 are novel HSP90AA1 clients and HSP90AA1 inhibitors can disrupt the LATS tumor suppressor pathway in cancer cells |
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NPHP4 inhibited LATS1-mediated phosphorylation of the Yes-associated protein (YAP1) and WWTR1, leading to derepression of these protooncogenic transcriptional regulators |
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phosphorylate Aurora B (AURKB) |
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PPP1R12A is a new substrate for LATS1 (LATS1 directly and preferentially phosphorylated serine 445 (S445) of PPP1R12A) |
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WWP1 is essential for LATS1 stability and negatively regulate LATS1 by promoting LATS1 degradation through polyubiquitination and the 26S proteasome pathway |
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disruption of the actin cytoskeleton promotes NF2-LATS1 interactions, which implicates NF2 in actin-mediated regulation of Hippo signaling |
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involved in phosphorylation of AMOT130, which is a key feature that enables it to inhibit YAP1-dependent signaling and cell growth |
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AMOT is a direct substrate of LATS1/LATS2 mediating functions of the Hippo pathway in endothelial cell migration and angiogenesis |
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NEDD4 directly interacts with LATS1, leading to ubiquitination and decreased levels of LATS1 and, thus, increased YAP1 localization in the nucleus |
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LATS1, LATS2 can synergize with F-actin perturbations by phosphorylating free AMOT130 to keep it from associating with F-actin |
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AJUBa recruits LATS1 to junctions in a tension-dependent manner |
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PTPN14 and WWC1 can induce the LATS1 activation independently and cooperatively |
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LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C |
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LATS1-mediated phosphorylation of the T7 residue of CDC26 disrupts its interaction with CDC16 |
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PARD3 promotes the interaction between PPP1CA and LATS1 to induce LATS1 dephosphorylation and inactivation, therefore leading to dephosphorylation and activation of TAZ |
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LMO3 promotes hepatocellular carcinoma invasion, metastasis and anoikis inhibition by directly interacting with LATS1 and suppressing Hippo signaling |