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FLASH GENE
Symbol PCDH10 contributors: mct/npt/pgu - updated : 28-05-2019
HGNC name protocadherin 10
HGNC id 13404
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal signal peptide
  • six extracellular cadherin domains
  • a transmembrane domain encoded by a large single exon
  • a C terminal cytoplasmic tail
  • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to murine Pcdh10 protocadherin 10
    intraspecies homolog to cadherin
    Homologene
    FAMILY
  • cadherin superfamily of calcium dependent cell-cell adhesion glycoproteins
  • protocadherin subfamily
  • CATEGORY adhesion , tumor suppressor , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane,junction
    text integral plasma membrane, localized at the synaptic junction
    basic FUNCTION
  • cadherin-related neuronal receptor, putatively involved in the specificity of neuronal connections
  • essential for both elongation of striatal axons and patterning of the putative guidance cues for thalamocortical projections
  • cadherin-related neuronal receptor thought to play a role in the establishment and function of specific cell-cell connections in the brain
  • PCDH10 is involved in angiogenesis and methylation correlated with multiple myeloma
  • PCDH10 is primarily required for linking ubiquitinated DLG4 to the proteasomal machinery
  • distinct roles for MEF2A, PCDH10 and FMR1 in regulated degradation of DLG4 and synapse elimination, suggesting a common deficit in activity-dependent synapse elimination among different genetic causes of autism
  • exhibits inhibitory roles in cancer cell motility and cell migration
  • adhesion molecule found to protect against tumorigenesis and essential for axonal elongation and actin dynamics during development
  • may influence subcellular actin cytoskeletal organization and axon-axon interactions in the course of familial amyloidotic polyneuropathy
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development , nervous system
    text
  • playing a putative role in cell-cell interactions critical in the development of the central nervous system, mediating adhesion in synaptic junctions through lack-in process
  • PATHWAY
    metabolism
    signaling signal transduction
    cell-cell signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • MEF2A and FMR1 cooperatively regulate the expression of PCDH10
  • PCDH10 is required for MEF2A-induced synapse elimination and functions to deliver ubiquitinated DLG4, a critical synaptic scaffolding molecule to the proteasome
  • transcriptional target of TP53
  • potentially important role of TP53 in regulating tumor cell migration through activating PCDH10 expression
  • cell & other
  • cells cell homophiic interaction
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation
    tumoral       loss of function
    inactivation may be a critical event in cervical cancer progression
    tumoral     --low  
    by promoter methylation in diffuse large B-cell lymphoma (DLBCL) but not in normal lymph nodes, suggesting that its epigenetic aberrance is essential to the lymphomagenesis
    tumoral     --low  
    in hepatocellular carcinoma, closely associated with poor prognosis of HCC patients
    constitutional     --over  
    in transthyretin-related familial amyloidotic polyneuropathy
    Susceptibility to autism spectrum disorder
    Variant & Polymorphism
    Candidate gene PCDH10 methylation is frequently involved in lymphomagenesis and could serve as a tumour-specific biomarker
    Marker
  • valuable biomarker for HCC
  • genetic deletion of PCDH10 represents an adverse prognostic marker for the survival of patients with CRC
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveuterus
    potentially useful therapeutic target for cervical cancer
    cancerhemopathy 
    potential therapeutic target for demethylating drugs in diffuse large B-cell lymphoma (DLBCL)in the future
    cancerdigestiveliver
    restoration of PCDH10 could be a valuable therapeutic target for HCC
    cancerbrainglioma/neuroblstoma
    may be a promising target for the therapy of glioblastoma
    ANIMAL & CELL MODELS