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FLASH GENE
Symbol KAT7 contributors: mct/pgu - updated : 15-01-2014
HGNC name K(lysine) acetyltransferase 7
HGNC id 17016
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal transcriptional repression domain
  • zinc finger domain (C2HC zinc finger)
  • histone acetyltransferase domain
  • a PHD domain
  • HOMOLOGY
    Homologene
    FAMILY
  • MOZ/SAS family
  • MYST family
  • CATEGORY enzyme , regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • regulation of AR-dependent genosin in normal and prostate cancer cells
  • positive regulatory factor for pre-RC (prereplicative complex) assembly
  • may be involved in the regulation of eukaryotic transcription
  • can acetylate nucleosomal histone H4
  • transcriptional coactivator
  • associating with replication origins specifically during the G1 phase of the cell cycle in a manner that depends on the replication licensing factor CDT1
  • integrates internal and external stimuli to coordinate transcriptional responses with initiation of DNA replication
  • H4-specific histone acetylase, is a coactivator of the DNA replication licensing factor CDT1
  • primary role in development is that of a transcriptional activator, which is indispensable for H3K14 acetylation and for the normal expression of essential genes regulating embryonic development
  • acetylates lysine residues of histones and is involved in DNA replication and gene transcription
  • promotes destabilization of estrogen receptor (ESR1) in breast cancers through lysine 48-linked ubiquitination
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • PHF17-KAT7 complex implicated in acute kidney injury, suggesting distinct roles for PHF17 isoforms during epithelial cell recovery
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • ORC1
  • AR
  • interacting with CDC2L2 (a novel regulator of MYST2)
  • directly interacting with CDT1
  • coactivator both for AP-1 transcription factors responding to stress-activated JNK kinases and also for the CDT1 licensing factor that ensures that DNA is replicated exactly once per cell cycle
  • importance of ING association with KAT7 in controlling cell proliferation
  • PHF17 bind KAT7 and promote acetylation of histones in chromatin context
  • BRPF1 activating 3 lysine acetyltransferases (KAT6A, KAT6B, and KAT7), suggesting that this protein has the potential to stimulate crosstalk between different chromatin modifications
  • cell & other
    REGULATION
    inhibited by GMNN, that inhibits KAT7 acetylase activity in the context of a CDT1-KAT7 complex, and it associates with origins and inhibits H4 acetylation and licensing
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    highly expressed in carcinomas of the testis, ovary, breast, stomach/esophagus, bladder
    constitutional     --low  
    expression was reduced in testes of patients with Androgen insensitivity syndrome, (AIS) compared to normal testes
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    modulation of ER stability by KAT7 in breast cancers may provide a novel therapeutic possibility
    ANIMAL & CELL MODELS