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FLASH GENE
Symbol SLC30A3 contributors: mct/pgu - updated : 02-09-2011
HGNC name solute carrier family 30 (zinc transporter), member 3
HGNC id 11014
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six transmembrane domains
  • HOMOLOGY
    interspecies ortholog to murine Znt3
    Homologene
    FAMILY
  • cation diffusion facilitator (CDF) family of metal ion transporters
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • membrane of synaptic vesicles
  • localized in clear synaptic vesicles of cortical glutamatergic terminals
  • basic FUNCTION
  • transport of zinc out of the cytoplasm into synaptic vesicles
  • evidently controls not only the "stainability" but also the actual mass of zinc in mossy-fiber synaptic vesicles (thus confirming its metal-transporting role in the brain)
  • responds to glucose- and zinc variations in beta-cells and is critical for insulin production during beta-cell stress
  • important for zinc homeostasis modulating presynaptic MAPK signaling and is required for hippocampus-dependent memory
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with AP3B1 and it is preferentially targeted to a distinct synaptic vesicle subpopulation
  • interacting with AP3B1, through its cytosolic tail
  • cell & other
    REGULATION
    activated by SERPINF1 in RPE
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the amyloid plaques of Alzheimer disease brain (
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    ZnT3KO mice showed normal memory for fear conditioning and passive avoidance, even under gradual training regimes designed to unmask potential ceiling effects in the expression of memory