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FLASH GENE
Symbol ABCG4 contributors: mct - updated : 29-08-2018
HGNC name ATP-binding cassette, sub-family G (WHITE), member 4
HGNC id 13884
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a single ATP-binding domain
  • a cluster of six transmembrane-spanning domains providing substrate specificity
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to Drosophila Atet protein
    ortholog to murine Abcg4
    intraspecies homolog to ABCG1 protein
    Homologene
    FAMILY
  • ABC transporter family
  • ABCG (White) subfamily
  • CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • hydrolyzes ATP
  • putatively involved in macrophage lipid homeostasis
  • may involve cholesterol transport
  • ABCA1, ABCG1, and ABCG4 are localized to distinct membrane meso-domains and disturb the meso-domain structures by reorganizing lipids on the plasma membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS nervous system
    text
  • potential role in cholesterol transport processes in brain
  • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ATP binding
  • interacting with ABCG1, in concert with ABCA1 to maximize the removal of excess cholesterol from cells and to generate cholesterol-rich lipoprotein particles
  • HUWE1 and NEDD4, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters
  • cell & other
    REGULATION
    induced by oxysterols and retinoids
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS