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FLASH GENE
Symbol GREB1 contributors: mct - updated : 17-04-2014
HGNC name growth regulation by estrogen in breast cancer 1
HGNC id 24885
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,nucleus
basic FUNCTION
  • play an important role in hormone-responsive tissues and cancer
  • play a pivotal role in hormone-stimulated breast cancer growth
  • may be critically involved in prostate cancer proliferation
  • unexpected role for GREB1 as an estrogen-specific ESR1 cofactor that is expressed in drug-sensitive contexts
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • in breast cancer cells, NR5A2 promotes cell proliferation by enhancing ESR1 mediated transcription of target genes such as GREB1
  • Il6/STAT3 modulates estrogen-induced GREB1 transcriptional activity in breast cancer cells
  • is a chromatin-bound ESR1 coactivator and is essential for ESR1-mediated transcription, because it stabilizes interactions between ESR1 and additional cofactors
  • cell & other
    REGULATION
    induced by ESR1
    Other regulated by androgens
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in estrogen-responsive positive breast cancersand prostate carcinoma
    tumoral     --over  
    promotes cell proliferation and increases the clonogenic ability in breast cancer cells
    Susceptibility to hypertension
    Variant & Polymorphism SNP 45718A>G, was significantly associated with hypertension and blood pressure level in men
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    novel gene target for therapeutic intervention
    ANIMAL & CELL MODELS