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FLASH GENE
Symbol ABCC11 contributors: mct - updated : 08-12-2021
HGNC name ATP-binding cassette, sub-family C (CFTR/MRP), member 11
HGNC id 14639
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two ATP-binding domains
  • two transmembrane regions
  • HOMOLOGY
    intraspecies homolog to MRP5
    Homologene
    FAMILY ATP binding cassette transporter subfamily C (CFTR/MRP)
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton,microfilament
    text co-localized with neurofilaments indicating that it is an axonal protein
    basic FUNCTION
  • acting as a multispecific organic anion pump which can transport nucleotides
  • involved in multi-drug resistance
  • playing a role in dehydroepiandrosterone 3-sulfate release from neurons to sites of dehydroepiandrosterone 3-sulfate-mediated receptor modulation
  • likely playing an important role in the generation of axillary malodour
  • plasma membrane protein involved in the transport of a variety of lipophilic anions
  • novel function of ABCC11/MRP8 in the regulation of pepsinogen I secretion in the normal gastric chief cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP-binding
    protein
    cell & other
    REGULATION
    Other N-linked glycosylation is likely important for the protein stability of ABCC11
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    expressed in aggressive breast cancer subtypes, and is associated with poor prognosis
    Susceptibility
  • to earwax type
  • to axillary osmidrosis
  • Variant & Polymorphism SNP
  • determinant of earwax type
  • SNP ABCC11 538G>A (G180R) is linked to axillary osmidrosis
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS