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FLASH GENE
Symbol ABCC11 contributors: mlc - updated : 12-04-2006
HGNC name ATP-binding cassette, sub-family C (CFTR/MRP), member 11
HGNC id 14639
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two ATP-binding domains
  • two transmembrane regions
  • HOMOLOGY
    intraspecies homolog to MRP5
    Homologene
    FAMILY ATP binding cassette transporter subfamily C (CFTR/MRP)
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microfilament
    text co-localized with neurofilaments indicating that it is an axonal protein
    basic FUNCTION
  • acting as a multispecific organic anion pump which can transport nucleotides
  • involved in multi-drug resistance
  • playing a role in dehydroepiandrosterone 3-sulfate release from neurons to sites of dehydroepiandrosterone 3-sulfate-mediated receptor modulation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP-binding
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast cancer
    Susceptibility to earwax type
    Variant & Polymorphism SNP determinant of earwax type
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS