basic FUNCTION
| epidermal keratinocyte lipid transporter involved in cellular lipid trafficking in keratinocytes |
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may play a critical role in the formation of lamellar granules and the discharge of lipids into the intercellular spaces |
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plays an important role in lipid transport from the Golgi apparatus to lamellar granule in granular layer keratinocytes (Sakai 2007) |
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its activity is required for the generation of long-chain ceramide esters that are essential for the development of normal skin structure and function, and for the generation of a specific class of lipids that are essential to the formation of the epidermal permeability barrier (Zuo 2008) |
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plays a critical role in the formation of the skin's permeability barrier via an effect on the generation of a highly specialized class of ceramide esters (Zuo 2008) |
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cellular membrane transporter that facilitates the delivery of glucosylceramides to epidermal lamellar bodies in keratinocytes, a process that is critical for permeability barrier formation (Jiang 2009) |
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plays an important role in regulating gene expression and regulates epidermal proliferation, differentiation, and wound healing (Jiang 2009) |