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FLASH GENE
Symbol SLC25A19 contributors: mct - updated : 17-12-2011
HGNC name solute carrier family 25 (mitochondrial deoxynucleotide carrier), member 19
HGNC id 14409
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three tandemly repeated mitochondrial membrane carrier domains (SOLCAR repeats)
  • six transmembrane spanning segments
  • HOMOLOGY
    Homologene
    FAMILY solute carrier family 25 mitochondrial
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • deoxynucleotides and dideoxynucleotides carrier maybe involved in the cytotoxicity of antiviral and anticancer nucleoside analogy
  • mitochondrial deoxyribonucleotide transporter, and mitochondrial thiamine pyrophosphate transport important for CNS development
  • required for the accumulation of coenzyme A in the mitochondrial matrix
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text energy transfer
    PATHWAY
    metabolism energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCPHA , SNBP
    Susceptibility
    Variant & Polymorphism
    Candidate gene recognized by igG from patients with active Grave disease
    Marker
    Therapy target
    ANIMAL & CELL MODELS