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FLASH GENE
Symbol EMILIN2 contributors: - updated : 26-08-2005
HGNC name elastin microfibril interfacer 2
HGNC id 19881
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal cysteine-rich domain (EMI)
  • C1q domain at the C terminus
  • a short collagenous stalk
  • eight potential N glycosylation sites
  • a prolinr rich sequence
    • conjugated GlycoP
    mono polymer homomer , trimer
    isoforms Precursor containing a putative polyadenylation site in the 3'UTR, a secretory signal peptide, a consensus signal cleavage site leading to a mature protein made of 1023 aa and a 112 kDa
    HOMOLOGY
    intraspecies homolog to murine Emilin2
    Homologene
    FAMILY EMILIN family, EMI domain containing superfamily
    CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION extracellular
    text cochlear basilar membrane component
    basic FUNCTION
  • may be responsible for anchoring smooth muscle cells to elastic fibers
  • may be involved not only in the formation of elastic fibers but also in the processes that regulate vessel assembly
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component EMILIN/multimerin/EMILIN 2
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts with EMILIN 1 via its C1q domain
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS