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FLASH GENE
Symbol F11R contributors: mct - updated : 16-12-2014
HGNC name F11 receptor
HGNC id 14685
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal signal peptide
  • two potential N glycosylation sites
  • an extracellular domain containing two extracellular IgV or C2-type loops
  • a short C terminal tail with a PDZ domain
  • HOMOLOGY
    interspecies homolog to murine Jcam1
    Homologene
    FAMILY
  • JAM family
  • CATEGORY adhesion , immunity/defense , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
        intracellular
    intracellular,nuclear envelope
    text integral transmembrane protein of tight junction, colocalizing with F actin at membrane ruffles
    basic FUNCTION
  • regulating the tight junction assembly in epithelia
  • counter-receptor for LFA1 controling transmigration during leukocyte recruitment
  • cell adhesion molecule of the immunoglobulin superfamily involved in platelet adhesion, secretion
  • plays a critical role in the function of endothelial cells and in platelet adhesion to inflamed endothelium
  • having with NKkappa B a function in the initiation of inflammatory thrombosis
  • JAM1, JAM2, JAM3 expressions on the lymphatic endothelium may contribute to both seal the cell-cell contact at interendothelial junctions
  • play an important role in the assembly and maintenance of tight junctions and in the establishment of epithelial cell polarity
  • in addition to the previously reported role of F11R in the initiation of plaque formation, F11R plays also an important role in the subsequent growth of atherosclerotic plaques
  • restricts intestinal epithelial cell (IEC) proliferation in a dimerization-dependent manner, by inhibiting AKT1-dependent CTNNB1 activation
  • unique tight junction (TJ) transmembrane protein that under basal conditions maintains endothelial cell-cell interactions but under inflammatory conditions acts as a leukocyte adhesion molecule
  • potential role in controlling perijunctional actin cytoskeleton in addition to its previously reported role in regulating claudin proteins and small-molecule permeability
  • cell adhesion molecule found on the surface of human platelets
  • key regulator of mesoangioblasts (MABs) extravasation
  • serve a crucial role in the proliferation, differentiation, and tube-like formation of epithelial cells during angiogenesis
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS coagulation/hemostasis , inflammation
    text platelet aggregation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physically and functionally associated with the PDZ domain-containing MLLT4 and PDZGEF2, but not zonula occludens (ZO)-1, in epithelial cells
  • Ca(2+) homeostasis in sperm is maintained by the relative ratios of CASK-ATP2B4 and CASK-F11R interactions
  • involvement of RHOA and ROCK1 in F11R relocalization
  • associates directly with TJP2 and indirectly with afadin, and this complex, along with RAPGEF2, activates the small GTPase RAP2C
  • regulates epithelial permeability via association with TJP2, afadin, and RAPGEF2 to activate RAP2C and control contraction of the apical cytoskeleton
  • ADAR, but not ADAR2, takes part in the editing of F11R however editing alone is not sufficient for obtaining an elevation in RNA levels
  • plays an important role in non-small cell lung cancer (NSCLC) progression
  • recruits CSK to the integrin-SRC complex in resting platelets
  • cell & other
  • receptor for retrovirus, required for activation NF-kappa B and apoptosis
  • REGULATION
    Other induced during differentiation of THP-1 dendritic cells and is independent of PPAR-gamma and the p38 MAPK pathway (Ogasawara 2009)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS