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FLASH GENE
Symbol PROK2 contributors: mct - updated : 18-11-2016
HGNC name prokineticin 2
HGNC id 18455
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal hexapeptide sequence (AVITGA)
  • cysteine rich domains forming disulfide bounds, 10 conserved cysteine residues within the 81 AA in its mature form
  • isoforms Precursor a 27 aa signal peptide of 2.9 kda and a 81 aa mature peptide
    HOMOLOGY
    interspecies homolog to rattus Prok2 (95.1 pc)
    homolog to murine Prok2 (94.1 pc)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • endogenous neurotrophic factor supporting neuronal survival through the activation of the MAPK/PI3K pathways
  • transmetting the behavioral circadian rhythm of the suprachiasmatic nucleus (SCN) by functioning as an output molecule from the SCN
  • functioning as a chemoattractant for SVZ-derived neuronal progenitors
  • may also act as a detachment signal for chain-migrating progenitors arriving from the rostral migratory stream
  • potently contracting gastrointestinal (GI) smooth muscle
  • modulating mobilization of haematopoietic cell mobilization from the bone marrow during tumour development
  • promoting angiogenesis
  • can be activated by pathological stimuli such as hypoxia-ischemia and excitotoxic glutamate and is a deleterious mediator for cerebral ischemia
  • potentiates the activity of acid-sensing ion channels in the primary sensory neurons
  • is a proalgesic factor and its signaling likely contributes to acidosis-evoked pain by sensitizing acid-sensing ion channels
  • PROK2 increases the activity of acid-sensing ion channels via the PROKR2 and protein kinase C-dependent signal pathways
  • is a regulator in the thermoregulation and energy expenditure
  • PROK2 may likely transmit circadian timing information to some neurobehavioral neural networks
  • both PROK1 and PROK2 have been found to regulate a stunning array of biological functions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS circadian , development
    text
  • rhytmically expressed in the SCN
  • neurogenesis
  • PATHWAY
    metabolism
    signaling
  • PROK2 signaling pathway has been shown to be a critical regulator of olfactory bulb morphogenesis and sexual maturation
  • a component complex PROC2/PROCR2 plays a role in GNRH1 neuron development beyond olfactory bulb morphogenesis
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PROK2-induced the formation of vessel-like structures by aortic endothelial cells expressing only PROKR1, and disorganized the tight junctions in hepatic sinusoidal endothelial cells expressing only PROKR2, confirming the divergent roles of these receptors
  • TBX20 is a novel transcription factor regulating angiogenesis through the PROK2-PROKR1 (prokineticin receptor 1) pathway in both development and disease
  • PROK1 and PROK2 bind to two highly related G protein-coupled receptors (GPCRs), prokineticin receptor 1 (PROKR1) and prokineticin receptor 2 (PROKR2)
  • cell & other
    REGULATION
    activated by CLOCK and BMAL1 heterodimers and light
    induced by granulocyte colony-stimulating factor
    inhibited by period genes (PER1, PER2 and PER3) and cryptochrome genes (CRY1 and CRY2)
    Other controlled by circadian clock
    ASSOCIATED DISORDERS
    corresponding disease(s) KAL4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS