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FLASH GENE
Symbol ERP29 contributors: mct - updated : 24-08-2011
HGNC name endoplasmic reticulum protein 29
HGNC id 13799
PROTEIN
PHYSICAL PROPERTIES globular Hydrophilic
STRUCTURE
motifs/domains
  • N terminal hydrophobic signal sequence, resembling the thioredoxin domain of protein disulfide isomerase, but lacking its redox-active function due to the absence of an active motif consisting of double cysteines
  • C terminal endoplasmic reticulum retention motif KEEL, but lacking the CXXC thioreduxin box motif
  • mono polymer dimer
    HOMOLOGY
    interspecies homolog to rattus Erp29
    intraspecies homolog to AGR2, TXNDC12
    Homologene
    FAMILY protein disulfide isomerase family
    CATEGORY chaperone/stress , enzyme , tumor suppressor , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • playing a role in the processing of secretory proteins within the endoplasmic reticulum
  • having a function in thyroid cells connected with folding and/or secretion of thyroglobulin
  • ERP29 function is critical for the folding/secretion of thyroglobulin (Tg), a major secretory product of thyroid cells
  • new role for ERP29 as a chaperone that helps stabilize monomeric GJA1 to enable oligomerization to occur in the Golgi apparatus
  • facilitates the transport of secretory proteins in the early secretory pathway
  • facilitates processing and transport of proteins in the early secretory pathway
  • biological role as a putative chaperone in the endoplasmic reticulum
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • dimerization of ERP29 is crucial for its protein unfolding function
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • regulates GJA1 trafficking and function
  • physical interaction with EIF2AK3 and moreover, overexpression of ERP29 enhanced endogenous levels of EIF2AK3 (ERP29 regulates response to doxorubicin by a EIF2AK3-mediated mechanism)
  • interplay between MAPK14 phosphorylation and DNAJC3 upregulation has key roles in modulating ERP29-induced cell-growth arrest and survival
  • cell & other
    REGULATION
    Other not responsive to metabolic stress
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    significantly inhibits proliferation and suppresses tumorigenesis by modulating ER stress signaling and the mesenchymal-epithelial transition in breast cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    in mice Erp29 may be one of the important factors involved in sperm fertilization by facilitating sperm-oocyte membrane fusion